Dual modes of membrane binding direct pore formation by Streptolysin O
نویسندگان
چکیده
منابع مشابه
Suicide cancer gene therapy using pore-forming toxin, streptolysin O.
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15 صفحه اولAssembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization.
Streptolysin O (SLO) is a bacterial exotoxin that binds to cell membranes containing cholesterol and then oligomerizes to form large pores. Along with rings, arc-shaped oligomers form on membranes. It has been suggested that each arc represents an incompletely assembled oligomer and constitutes a functional pore, faced on the opposite side by a free edge of the lipid membrane. We sought functio...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2015
ISSN: 0950-382X
DOI: 10.1111/mmi.13085